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Non-responsive patients, requiring a low methionine diet and betaine supplementation (regardless of vitamin B 6 therapy), were assigned a vitamin B 6 responsiveness score of 1

doi: 10.1007/978-981-15-4759-1_5 149 YangZHeYWangHZhangQ

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Lets consider a few of them: Hyaluronic acid Studies have indicated that oral administration of hyaluronic acid can improve skin, including one study from 2023 that saw improved hydration after 2-8 weeks, skin tone after 4-8 weeks, and dermal thickness after 12 weeks.40 Vitamin C Vitamin C may have more additional benefits, alongside skin health, than the other supplements in this section, but its worth noting that oral intake of just 100mg/day resulted in measurable increases in free-radical scavenging in the dermal cells of volunteers in a small clinical study.41 42 You may not even need a supplement to reach that 100mg goal, either