dr robert keller original glutathione Formula (OGF™) Robert Keller, MD - Catawba

Numerous compounds have been used to inhibit the activity of endogenous mammalian G6PDH in vitro and/or in vivo such as the naturally occurring adrenal steroid dehydroepiandrosterone (DHEA) 3 , catechin gallates, especially epigallocatechin gallate (EGCG) 4 , chelerythrine (initially a PKC inhibitor) and PP2 (Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine), primarily a Src kinase family inhibitor 5

Glutathione may be a critical link

Tschirhart E, Bertrand C, Theodorsson E, Landry Y

It helps reduce oxidative stress

Mdm2, but not MdmX, also acts as an E3 ligase to further suppress p53 activity by tagging it with polyubiquitin, leading to p53 destruction in the proteasome 10