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Tumour necrosis factor (TNF-) plays a crucial role in both normal and tumour cells and is a widely studied cytokine 26

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Together, these interconnected pathways establish a compartmentalized antioxidant defense architecture that critically determines ferroptosis sensitivity

As an endoglycosidase, heparanase cleaves heparan sulfate chains, thereby releasing growth factors and other bioactive molecules anchored to the extracellular matrix (ECM)

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