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In addition, ROS can activate the expression of the nuclear transcription factorkappa, which upregulates the expression of many genes involved in MS, such as tumor necrosis factor and nitric oxide synthase, among others, leading to mitochondrial dysfunction and energy deficits that result in mitochondrial and cellular calcium overload

Effective Topical Agents and Emerging Perspectives in the Treatment of Psoriasis: Keratolytics

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In most cases, that difference comes down to quality and context