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At the curve's inflection point, pH = pKa, the system is most resistant to changes in pH when either acid or base is added

The (1.55 CSF) term is included because CSF contains more water than GM or WM, and thus CSF tends to lower water-scaled estimates of the metabolites, in addition to the usual partial volume effects 11

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45 Nonetheless, RIG-I, not MDA5, appears to interact with the Mtb-specific mRNAs polA and ppe11 (ref

[1] Deamidation proceeds much more quickly if the susceptible amino acid is followed by a small, flexible residue such as glycine whose low steric hindrance leaves the peptide group open for attack