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Overdosage Rare cases of toxicity have been reported or death by overdose with glucocorticoids

4.2.3 Dual-substrate-competitive inhibitors Dual-substrate-competitive inhibitors compete with the both substrates (SAM and NAM) for the binding sites in NNMT, thereby increasing inhibitors activity and selectivity (Table 1 and Figure 6, such inhibitors mainly include MvH45 (Van Haren et al., 2017), AK-12 (Ruf et al., 2022), MS2756 ( MS2734 ( GYZ-78 ( NS1 ( LL320 ( CC-410 (Roberti et al., 2023)

Apart from vegans and people with gastrointestinal conditions, infants and children from B12-deficient mothers and the elderly are at particular risk of B12 deficiency