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Am J Physiol-Heart Circ Physiol

Below, we break down the details from notable pieces of research, including the outcomes of a few completed clinical (human) trials

These results suggested a wide safety margin

(2008), measures of enzyme activity were used (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase), allowing a gauge of trauma response (proteolysis) and therefore the ability to further understand the mechanisms of action