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PLoS ONE 7 , e43515 (2012)

Biogenic amines and the states of sleep

While sub-threshold concentrations of each ligand alone did not alter basal spinogenesis, combined sub-threshold concentrations of 30 " M Dihexa and 2.5 ng/ml HGF or 10 " 13 M Nlel -AnglV and 2.5 ng/ml of HGF produced a near ceiling effect, similar to biological responsive doses of each ligand alone (Figure 1 1 A and B)

Moreover, this study also indicated that GLS inhibition significantly impaired the production of antioxidant glutathione in types of AML cell lines, leading to increased mitochondrial ROS (mitoROS) and cell apoptosis [11, 17]