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EZH2 inhibitors, such as GSK126 enhance angiogenesis but risk vascular stiffness, whereas KMT2B knockdown reduces iron death but may impair other H3K4me3-dependent pathways

Methionine is non-polar and is the initiator amino acid in protein synthesis, being the first one incorporated into protein chains

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Excess PUFA accumulation, depletion of GSH, and iron overload markedly heighten ferroptosis susceptibility