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Results: Among 771 adolescents included in NHANES 2017-2018 [mean age 14.7 years

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Such clinical findings were confirmed in vitro , with oxidative stress identified to be partially involved in NLRP3-mediated IL-1 secretion by monocyte cultures exposed to SARS-CoV-2

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Additional studies also report that chronic inflammation impairs key intracellular signaling cascades, such as PI3K/Akt and mTOR, in granulosa cells, thereby promoting ROS accumulation and impairing follicular maturation (Gonnella et al., 2022)

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