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A dynamic equilibrium exists between E- and Z-profoxydim, as previously described by our research group for photodegradation processes involving cyclohexanediones such as alloxydim 10 and clethodim 9

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These conditions involve distinct mechanisms characterized by severe impairment of the BBB, infiltration of peripheral blood and immune cells, and significant alterations in the cerebellar microenvironment, leading to rapid and pronounced neurodegenerative events