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doi:10.1016/j.bbcan.2014.05.004

Ito T, Kidouchi K, Sugiyama N, Kajita M, Chiba T, Niwa T, et al

Additionally, CAR-T cell therapies are hampered by severe toxicities, limited efficacy in solid tumours, resistance mechanisms in B-cell malignancies, antigen escape, inadequate persistence and trafficking, and the presence of an immunosuppressive TME [61]

Taken further, Th2 cells from asthmatic human patients PBMCs treated with pterostilbene in vitro, saw inhibited CD4+IL-4+ cells with HDM stimulation [207]