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Damaged kidneys cannot efficiently filter and excrete excess magnesium, which can lead to a dangerous condition called hypermagnesemia, characterized by muscle weakness, severe low blood pressure, and cardiac arrhythmias

Further, NMN can reverse the activity of endogenous SIRT3 in the liver of Bmal1 knockout mice, restore mitochondrial lipid oxidation in circadian rhythm mutants, and thus enhance hepatic mitochondrial respiratory function [21]

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