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INTERVENTION: Patients were randomly assigned to receive ointment containing 7% sucralfate or a placebo ointment consisting of petroleum jelly

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In the first part of this thesis, the aim was to study the role of mitochondria in adipose tissue in mitochondrial disease and in acquired obesity

Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]

Furthermore, preconditioning fibroblasts in a culture medium that relies exclusively on lactate as a fuel source leads to a transition from OXPHOS to glycolysis