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AOD 9604, because it works specifically on adipose tissue through lipolytic pathways, theoretically targets fat preferentially

This is because all baby ruminant animals (calves, lambs, kids, fawns, etc.) are not born with a fully functional rumen (nor a reticulum, nor an omasum)

This results in an increased inflammatory response, which damages tissue cells, such as vascular ECs and pancreatic -cells, ultimately leading to Mets

They suppress excessive immune responses and maintain tolerance to harmless substances

By inhibiting NF-kB activation, it could potentially reduce the inflammatory cascade that drives flare severity without compromising the immune response to concurrent infections, a common concern during lupus flares when patients may also be on immunosuppressive medications