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Nicotine itself is not benign, but on its own its much less harmful than the smoke and tar produced by burning tobacco

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(C) Treatment involved administration of 30 mg/day of methylprednisolone followed by prednisolone over a 10-day period, leading to improvements that were visible on the follow-up chest radiograph

In fact, in the mid-1990s FDA attempted to regulate traditional cigarettes and smokeless tobacco products as drug delivery devices