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The cardiometabolic benefits were consistently more pronounced in female participants, with women experiencing about a 5% reduction in total cholesterol versus 3% in men, and a 10% reduction in LDL cholesterol versus 4% in men

Badman, M.K

A delayed adverse drug effect or interaction could easily occur with vitamin B12 since the time necessary for most patients to become deficient can be delayed one or more years due to high storage levels in the body