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Concurrent ELISPOT analysis and multiplex cytokine analysis corroborated flow cytometry findings, with exclusively priming-phase pre-immunization (day 1) group significantly enhancing antigen-specific T cell responses and IFN- secretion than the vaccine-alone group (Supplementary Fig

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however, intramuscular B12 is preferred for patients with neurological symptoms

Animal experiments After a 1-week acclimatization period, male C57BL/6 mice were orally gavaged with 150 mg/kg of metformin