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These technologies have been used to depict the GSH metabolic network, helping researchers to screen new drug targets (such as targets for key enzymes in GSH synthesis or metabolism) and biomarkers (such as GSH-related metabolite markers for disease diagnosis and prognosis assessment)

have reported that the existence of Cu-A complexes reduce the expression of LRP1 (lipoprotein receptor-related protein 1), further reducing the clearance of neurotoxic A and increasing brain A deposits

Normally brain concentrations of iron are not influenced by circulating iron levels, due to correct functioning of the blood-brain barrier and blood-cerebrospinal fluid barrier

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Low iron stores may influence dopaminergic and serotonergic signaling, affecting emotional regulation