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Cardiovasc Toxicol 21 , 593604 (2021)

Store them away from sunlight and heat

Considering the fact that L-arginine has links to cardiovascular complications, adding an unknown amount of betaine into the mix could make this an unwise choice for women with heart problems.18 For everyone else, the electrolyte complex and arginine content serve to make this one of the better stimulant-free pre-workouts out there

It upregulates the expression of early growth response protein 1 (EGR-1), a transcription factor that controls over 30 downstream genes involved in cytokine production, growth factor signaling, and extracellular matrix remodeling