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For NAD+-mediated skin benefits that are actually validated, niacinamide applied topically remains the more evidenced choice

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The interaction of the C-terminal residue VP3-Phe236 in CVB3 is absent in the wt PV2-CP17 structure as the C-terminus of VP3 is disordered in the latter, the final observed residue in wt PV2 being VP3 Ala235 (Fig