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Although methotrexate was first introduced as an antiproliferative agent that inhibits the synthesis of purines and pyrimidines for the therapy of malignancies, it is now clear that many of the anti-inflammatory effects of methotrexate are mediated by adenosine

Epigenetic mechanisms in the pathogenesis of Lynch syndrome Inherited defects in the DNA mismatch repair (MMR) system, MLH1 , MSH2 , MSH6 , and PMS2 genes, underlie Lynch syndrome, one of the most prevalent cancer syndromes in man