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The images were posted on the 4chan discussion board and were soon distributed via several blogs and media outlets, leading to the "Sad Keanu" meme being spread on the internet

You should contact your GP if you experience: Persistent fatigue or weakness that affects daily activities Tingling, numbness, or pins and needles in your hands or feet Difficulty with balance or coordination Memory problems or difficulty concentrating Mood changes, particularly low mood or irritability A sore, red tongue or recurrent mouth ulcers Unexplained shortness of breath or palpitations These symptoms warrant investigation, which typically includes blood tests to measure B12 levels (or active B12 depending on the laboratory), full blood count to assess for anaemia, folate levels, and potentially other tests such as anti-intrinsic factor antibodies if pernicious anaemia is suspected

doi: 10.1126/science.1104819 63 GreigSLKeatingGM

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