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Conclusion Collectively, the current study implied that supplementation of multistrain/multispecies synbiotic (250 mg/day) concomitant with L-carnitine (2 500 mg/day) for 8 weeks resulted in greater amendment in anthropometric and glycemic indices, and HDL-C in healthy female individuals with obesity without any severe side effects, indicating that L-carnitine + synbiotic co-supplementation seems to be more beneficial to ameliorate the mentioned parameters, compared with L-carnitine individual therapy