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Apart from SCFAs, other mechanisms might exist by which the microbiome regulates hunger and satiety

VIP impairs acquisition of the macrophage proinflammatory polarization profile 13 , and alters the Th1/Th2 balance in CD4 T cell differentiation in favour of Th2 cells, stimulating the acquisition of a Th17 non-pathogenic profile and inducing regulatory T cells (Treg) 14