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The presence of resistance phenotypes in the vaginal microbiome poses a major threat to human health, with some infections leading to infertility, widespread scarring in the genital tract, miscarriage and preterm birth, and an increased risk of co-infections with human immunodeficiency virus (HIV) 6,7,8

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Microbes regulate SCFA production, enhancing colonic 5-HT synthesis via TPH1 in Enterochromaffin Cells [23,93,94]

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