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Future investigations should give priority to dissecting the precise molecular crosstalk within the gut microbiota-ferroptosis axis and evaluating combined therapeutic strategies in preclinical models and clinical trials to validate their translational potential for OA

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AOD-9604 Research Applications & Key Findings Metabolic and Obesity Research Weight Loss and Fat Reduction Studies Initial clinical trials in obese adults showed promising results, though later studies revealed limitations

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Many researchers have focused on investigating the impact of ICB treatment on the interactions between immune cells and cancer cells in the tumor microenvironment (170, 183185), including the tertiary lymphoid structures (186190), as well as the T cell phenotypes in the peripheral circulation (191197)