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This dependency creates therapeutic vulnerabilities that can be exploited to selectively impair tumor survival, overcome drug resistance, and enhance sensitivity to conventional therapies (Fig

A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity

In this work, we report a biomimetic synthetic strategy for the massive and facile preparation of porous single-atom Fe nanozymes (pFeSAN) using hemoglobin (Hb) as Fe-source embedded inside zeolitic imidazolate framework (ZIF-8), which solve the above-mentioned challenges (Fig