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In atherosclerotic blood vessels, cholesterol crystals stimulate an immune cell inflammasome called NLRP3 that then triggers a cascade of inflammatory and thrombotic signaling

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However, many exposers in todays world deplete glutathione levels such as alcohol, artificial sweeteners, tobacco smoke, acetaminophen/Tylenol, toxic metals like mercury, artificial food dyes, and many common household chemicals

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This effect was abolished when system xCT was pharmacologically inhibited in the nucleus accumbens (NAc) using (S)-4-carboxyphenylglycine, directly linking cystineglutamate exchange to diminished relapse-like behavior