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It does not have FDA approval for any specific indication

Hattori K, Tanaka H, Wakabayashi C, Yamamoto N, Uchiyama H, Teraishi T, Hori H, Arima K et al (2011) Expression of Ca 2+ -dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients

This is most relevant when vitamin B12 deficiency is being corrected and broader B-vitamin support is clinically appropriate, where symptoms include a combination of fatigue, neurological features, and stress, or where rapid repletion and functional support are desired

doi: 10.1158/0008-5472.CAN-11-2474 59 KumariNDasABhattAN

This is one of the reasons published Tirzepatide research is typically discussed not only in terms of efficacy, but also in terms of tolerability during escalation , GI event burden and the balance between metabolic benefit and dropout risk