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86 The oral anti-diabetic drug metformin can also reduce the stability of SLC7A11 by inhibiting UFMylation of SLC7A11, and its combination with sulfasalazine can synergistically induce ferroptosis in breast cancer cells

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Moreover, in the mechanical claw pressure test, CGA effectively relieved diabetic neuropathic pain, likely by lowering blood glucose levels and reducing oxidative stress [169]

Cyclosporin A (CsA) binds to cyclophilin D in mitochondria, targets MPTP and inhibits its excessive opening, thereby attenuating apoptosis and mitochondrial damage, and it has shown promising efficacy in in vivo experiments (animal models) (Chen et al., 2021a)

Animals The GCLM knockout (KO) mouse line (characterized previously 16 ) has been backcrossed into the C57BL/6J background for more than 10 generations