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These findings suggest that topiramate may exert dual effects on oxidative stress, offering neuroprotection in certain contexts while exacerbating oxidative stress under different conditions and dosages

Front Physiol 10:1170 Sahu R, Upadhayay S, Mehan S (2021) Inhibition of extracellular regulated kinase (ERK)-1/2 signaling pathway in the prevention of ALS: target inhibitors and influences on neurological dysfunctions