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At the same time, melatonin treatment significantly inhibited the oxaliplatin-induced increase in the mRNA expression of cytokines such as interleukin-1 (IL-1), tumor necrosis factor- (TNF-), monocyte chemoattractant protein-1 (MCP-1), and monocyte inflammatory protein-1 (MIP-1) in the spinal dorsal horn [48]

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this phenomenon has been linked with the increased resistance at doxorubicin treatment due to the lack of CT2 in the cell membrane that, in turn, impairs drug entry into cancer cells (Novak et al., 2015)

Example spectra from the pgACC and dACC are shown in Fig

In addition, metabolites associated with amino acid metabolism and redox balance, such as lysine, arginine, and spermine, display multiple interactions with other metabolic nodes