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70 Additionally, lactylation at K91 of transcription factor EB (TFEB) impedes it from interacting with E3 ubiquitin ligase WW domain-containing E3 ubiquitin protein ligase 2 (WWP2), thereby inhibiting TFEB ubiquitination and proteasome degradation and eventually augmenting TFEB activity

Sex differences by design and outcome in the safety of Urate Elevation in PD (SURE-PD) trial

In these patients, there is a higher rate of metabolic syndrome, and NAC helped restore healthy insulin levels and sensitivity

The latter (amyloid plaques and tau tangles) affect optimal brain function and are hallmarks of Alzheimers disease

Salvati, E