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It is believed to interact with several areas of the central nervous system, including the hypothalamus, where it influences human circadian rhythms and the initiation of sleep

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This disruption allows senescent cells to undergo apoptosis, making FOXO4-DRI a promising senolytic agent for anti-aging and therapeutic applications

The reaction mixture, comprising 100 l 3 mM Gly-Phe-pNA substrate, 100 l appropriately diluted enzyme solution, 500 l 100 mM Tris-HCl buffer (pH 8.0) and 300 l water, was incubated at 303 K for 120 min

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