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ROS-associated tumor immunity in ICI therapy ICIs activate the immune systems attack on tumors by inhibiting immunosuppressive molecules on the surface of tumor cells, such as PD-1, PD-L1, and Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4)

Stimulation of macrophages with HGF results in differentiation of M1 macrophages to M2 subtypes (64), underscoring the functional relevance of HGF/Met axis in the antitumor immune response

Starting at the lower end of ranges and titrating based on response is always prudent

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Patient labs included WBC of 3220/L, Hgb of 10.3 g/dL, and normal platelet count of 255,000/L