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Thus, our findings suggest that inflammatory caspases could be important novel therapeutic targets in the comprehensive treatment or prevention of both neovascular and nonexudative AMD, and indicate that targeting inflammatory caspases may inhibit AMD more potently than when targeting Nlrp3 or IL1 signaling

The table below organizes what the literature actually shows, with the evidence tier stated explicitly (clinical human data, preclinical lab/animal data, or anecdotal/inferred)

10.1016/j.jalz.2019.01.010 9 AmaseneM.BesgaA.EcheverriaI.UrquizaM.RuizJ

Employing an AI-human negotiation approach, Lin et al designed a class of minimal model peptides targeting tuberculosis (TB), with K7W6 demonstrating potent efficacy, attributed to its assembly-inducing function

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