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Human SOD differs from the intracellular pathogens in having Cu/Zn and Mn as metal cofactors

In addition, the gut microbiota is closely related to autoimmune diseases that arise as a result of the hosts immune system attacking host tissues

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Longer GAA repeats result in a more severe reduction in FXN expression (6595% decrease with respect to healthy controls) and are associated with early disease onset and greater disease severity (Figure 2)