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The mechanisms proposed are consistent across organ systems: reduced oxidative stress, modulation of inflammatory cytokine cascades, and support for local microcirculation through angiogenic activity

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The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUCo-iast) or extrapolated to infinity (AUCo- ), C ma x concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (tj 2), volume of distribution (Vd), and clearance (CL)

International journal of molecular sciences, 19(7), 1987

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