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Meanwhile, the discovery of a large number of natural products has revealed broad prospects for bidirectional intervention of copper mortality through direct targeting of FDX1 and regulation of copper homeostasis

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46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008

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