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ex DC., exhibits well-documented anti-inflammatory activity ( PUN, a major polyphenol found in the peel of Punica granatum L., exhibits antioxidant and anti-inflammatory properties ( Collectively, these studies implicate autophagy-linked signaling pathways involving PI3K/AKT/mTOR, ULK1/Beclin-1/VPS34, p62/Nrf2, and AMPK/mTOR/ULK1 as a convergent axis through which linarin, Lico A, and PUN ameliorate the phenotypes of MAFLD ( 7 Perspectives and conclusion The prevalence of MAFLD is increasing worldwide, driven by an interconnected pathogenic network that includes IR, lipotoxicity, oxidative stress, mitochondrial and ER stress, chronic low-grade inflammation, and gutliver axis dysfunction

To further demonstrate the scalability of CHAMP, we screened a library comprising 1152 azide-bearing compounds that was recently described by the Dong and Sharpless groups in their strategy to install azide tags onto molecules using a diazotizing reagent 32

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10.1111/IJFS.13323 56 KhanK