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doi: 10.1111/j.1572-0241.2003.07385.x

This effect is notably reduced in adipocytes from obese individuals, suggesting that impaired cGMP signaling may contribute to the insulin resistance observed in T2DM

However, you can still get plenty of B12 on a vegan diet with help from a supplement, or in sources like fortified breakfast cereals

Solution : To enhance protein stability, it is essential to use gentle purification conditions and include stabilizing agents in buffers, such as protease inhibitors or stabilizers