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Thus, NRF2-addicted cancers adopt highly specialized metabolism favoring glutathione synthesis that is essential for the potent anti-oxidant and detoxification capacities, which cannot be achieved by a simple activation of NRF2

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mtROS-mediated Akt/AMPK/mTOR pathway was involved in copper-induced autophagy and it attenuates copper-induced apoptosis in RAW264.7 mouse monocytes