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superoxide anion) play fundamental role in oxidative stress and oxidative damage in biological systems The primary role of oxidative stress (OS) in the etiology and progression of several disease conditions is evident by a number of clinical and experimental studies

however, in some cases, mild abdominal discomfort may occur

Urinary metabolomics analyses have further indicated that Huang-qi injections can modulate amino acid metabolism, the tricarboxylic acid (TCA) cycle, fatty acid metabolism, vitamin B6 metabolism, and purine metabolism in cisplatin-induced nephrotoxic rats ( Through comprehensive investigations into the cardiotoxicity of various anti-tumor drugs, AS-IV has demonstrated a broad capacity to attenuate toxicity

Another limitation is that using siblings as a comparison group, the age difference between the two groups can introduce some bias, and this must be taken into account in interpreting the results

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