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it also serves as a critical signaling mechanism within cells by sensing the presence of oxidative stresses and, in turn, turning on other important protective systems in the cell

Alvarez-Suarez et al., The Composition and Biological Activity of Honey: A Focus on Manuka Honey, 3 Foods 420-32 (2014)

Together, these findings support a model in which GSTs exert bidirectional control over pyroptosis with GSTM1 and GSTP1 dampening inflammasome execution, whereas GSTO1 derepresses inflammasome assembly

Furthermore, the inhibition of ferroptosis represents a novel therapeutic target for OA management (152, 153)

Chen, M.-S

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