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The investigations of the present study revealed diminished Nrf2 and HO-1 expression in HG-induced HK-2 cells in vitro and in an in vivo DN model

CKD causes endothelial dysfunction by reducing NO production and increasing oxidative stress, which impairs vasodilation and blood flow to penile tissue [136]

TLK286 showed interesting in vitro and in vivo antiproliferative activity on cells with high GST P1-1 expression as a result of selection for doxorubicin, cyclophosphamide, and platinum resistance (Morgan et al., 1998