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Addissouky TA, et al

The reports mentioned above are qualitative in nature, and the loss of quantitative definition directly limits insights into what features are reproducible across studies

176 PinceticABournazosSDiLilloDJMaamaryJWangTTDahanRet al

Poly ADP-ribosylation, also known as PARylation, is a type of PTM in which polymers of ADP-ribose are covalently attached to target proteins by PAR polymerase (PARP) enzymes, resulting in a dramatic electrostatic change of the acceptor protein surface 128

Based on the electrophysiological studies, the VGCCs are classified into five different types, i.e., L-, N-, P/Q-, R-, and T-type (Catterall, 2000)