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Experimental results showed that metformin effectively lowered total testosterone levels and free androgen index ( Metformin exerts its efficacy by effectively reducing blood glucose levels, mitigating IR, and facilitating improvements in abnormal glucose metabolism markers

Additional roles confirmed included protein folding, cell cycle regulation, apoptosis, ferroptosis, and ascorbate metabolism

Mitochondrial dysfunction leads to the decrease of NAD + level, resulting in lysosomal acidification and impaired autophagy, and induces ferroptosis, involving the accumulation of iron in lysosomes and lipid peroxidation

Exercise did not affect glucose tolerance in CD fed MS-NASH mice

There were two blocks, each one including 192 trials (64 for each condition: shape, color or number)