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doi: 10.3390/cells13090749 68

The GPX family is well established today for its redox properties in balancing oxidative homeostasis in cells

Measurement of the levels of intracellular GSH and the relative expression of NRF2, GPX4 and SOD1 in tissue samples following neoadjuvant chemotherapy To further verify the role of GSH metabolism in chemotherapy resistance, we analyzed breast cancer data from the Gene Expression Omnibus (GEO) dataset (GEO: GSE140494)

Natural resources have long been a useful source of possible treatments

2 Methodology Relevant recent information on oxidative stress, free radicals, reactive oxidative species, and natural and synthetic antioxidants was collected by researching electronic databases such as PubMed/Medline, Web of Science, and Science Direct using the following MeSH terms: Antioxidants/analysis, Antioxidants/metabolism, Antioxidants/therapeutic use, Diet, Food Analysis, Forecasting, Free Radicals/adverse effects, Free Radicals/antagonists and inhibitors, Free Radicals/metabolism, Humans, Lipid Peroxidation/physiology, Reactive Oxygen Species/adverse effects, Reactive Oxygen Species/metabolism, Reactive Oxygen Species/therapeutic use, Antioxidants/metabolism Free Radicals/adverse effects, free Radicals/metabolism, Humans Oxidative Stress Oxygen/metabolism