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GHK-CU is a copper(II)-complexed tripeptide (molecular weight: ~401 g/mol) consisting of glycine-histidine-lysine chelated to copper ions, naturally present in human plasma

The antinociceptive impact of DSIP was negated by the opioid antagonist naloxone and was not observed in morphine-tolerant mice, suggesting that DSIP acts at the supraspinal level, possibly influencing opioid receptors [11]

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The peptide stimulates osteoblast activity via VEGFR2-nitric oxide signaling, enhancing bone matrix deposition